Are they sitting in a circle or in a line?
For the case that they're in a line, think of it like this. Make the 10 girls stand in a certain order, and let the boys squeeze in anywhere between 2 girls.
_G_G_G_G_G_G_G_G_G_G_ (10 girls standing in a line - there are 11 spots _ which the boys can take). Think of it like 4 out of the 11 spaces must pick a boy to stand in its place.
There are 10! ways the girls can stand in this formation, and 11P4 positions for the boys. Therefore the total arrangements are 10! x 11P4
The circle has similar reasoning (just harder to illustrate on the computer) but using the spacer method is probably the easiest.